抗胆碱能药物曲司氯铵分析方法进展

Analytical Methods for Anticholinergic Trospium Chloride: A Review

中文关键词:  曲司氯铵  原料药  制剂  生物样品

英文关键词:trospium chloride  PAI  preparations  biosamples

中文摘要:

      曲司氯铵是一种抗胆碱能药物,用于治疗膀胱过度活动症引起的尿频和尿失禁. 曲司氯铵较其它药物耐受性更高,病人使用更为安全,但其检验方法报道不多. 对曲司氯铵的分析方法(包括滴定法、紫外分光光度法、高效液相色谱法、气相色谱法、液体闪烁计数法等)进行了评述和展望.

英文摘要:

      Trospium chloride is one of anticholinergic medicines which can effectively relieve overactive bladder (OAB) with symptoms of urge incontinence and frequent micturition. Due to its higher tolerability, trospium chloride is safer to patients compared with other medicines. However,only a few articles on the analysis of trospium chloride and no relevant reviews are published till now. In this paper, the quantitative analytical methods for trospium chloride, including titration, UV spectrophotometry, HPLC, GC, and liquid scintillation counting (LSC), are reviewed with the prospacts of their developments.