气质联用法分析氘代医药中间体

Determination of the Purity of Deuterated Pharmaceutical Intermediates by Gas Chromatography-Mass Spectrometry

中文关键词:  MSD检测器,质荷比,氘代,医药中间体

英文关键词:MSD detector,abundance ratio,deuterated

中文摘要:

      探讨用HP-5毛细管色谱柱，MSD作检测器，以质荷比相对丰度的面积归一方法，定量测定质子泵合成中间体氘代产物的纯度.用此方法测定标准品及氘代苯、氘代蒽结果误差小于2%.实验表明，质荷比相对丰度归一方法简单、快速、灵敏度高，可用于定性、定量监控反应的进行，适用于氘代化合物纯度的测定.

英文摘要:

      The sample were injected into HP-5 capillary column and analyzed with MSD detector. The proton pump deuterated compound was dissolved in acetonitrile. The purity was determined by the relative abundance ratio normalization calculation. The results of the Standard and perdeuterobenene tests were satisfying;the detection relative errors were not more than 2%. It can be used for the determination of the purity in deuterated compound rapidly and sensitively ,and especially used for monitoring a reaction process.