流动注射化学发光测定硝苯地平的含量

Determination of Nifedipine by Its Inhibitory Action to Chemiluminescence

中文关键词:  化学发光  抑制法  硝苯地平

英文关键词:chemiluminescence  inhibitory method  nifedipine

中文摘要:

      建立了流动注射化学发光抑制法测定硝苯地平含量的新方法,将硝苯地平与硫酸铈铵的氧化还原反应与Ce(Ⅳ)Na₂SO₃氟哌酸化学反应相偶合,硝苯地平在10^-6～10^-4g/mL的范围内呈良好的线性关系,r=0.9992,检测下限为0.6μg/mL,相对标准偏差为3.2%(6×10^-5g/mL,n=11),方法简便、快速、结果可靠.

英文摘要:

      A new chemiluminescence method for the determination of nifedipine was studies. The principle of the method is that the reduction reaction of nifedipine by Ce(Ⅳ) is coupled with the chemiluminescence reaction of Ce(Ⅳ)-Na₂SO₃-norfloxacinum, and then quantitate the nifedipine by determing the released chemiluminescence signal. The linear range of the working curves is in 1.0×10^-6～1.0×10^-4g/mL nifedipine, the detection limit of nifedipine is 0.6 μg/mL, the relative standard deviation is 3.2%(6.0×10^-5 g/mL, n=11). The method is simple, rapid and reliable.