西替利嗪-碘铂酸缔合微粒体系的吸收光谱研究及分析应用

Absorption Spectral Study of the Nanoparticle System of Ctirizine-H2PtI6 and Its Analytical Application

中文关键词:  西替利嗪(CTRZ)  缔合微粒  吸收光谱  共振散射

英文关键词:citirizine  association nanoparticle  spectrophotometry  resonance scattering

中文摘要:

      Pt(IV)与I^-形成[PtI₆]^2-,[PtI₆]^2-和盐酸西替利嗪(CTRZ)通过静电引力作用形成疏水性的(PtI₆—CTRZ)缔合物分子.由于(PtI₆-CTRZ)缔合物分子间存在较强的分子间作用力和疏水作用力而生成紫红色(CTRZ—PtI₆)_n缔合微粒,在310、400、610nm处产生3个共振散射峰;在350～740nm波长范围的吸光度值均增大.在选定条件下,CTRZ浓度在0～10μg/mL范围内与A_580nm成正比,摩尔吸光系数ε_580nm为1.30×10⁴L/(mol·cm).实验结果表明,(CTRZ—PtI₆)_n缔合微粒的形成是导致同步散射信号增强的根本原因,而纳米纳米微粒的颜色是共振散射所致.

英文摘要:

      In 0.01 mol/L HCl medium, [PtI₆]^2- and I^- combine to [PtI₆]^2-. [PtI₆]^2- reacts with citirizine(CTRZ) to form (CTRZ-PtI₆) association molecule.The molecules aggregate automatically, owing to strong hydrophobic and molecular forces. (CTRZ-PtI₆)_n association nanoparticles in violet-red color were observed.It exhibits three resonance scattering peak at 310 nm, 400 nm, 610 nm, and there is a synchronous scattering peak at 470 nm. The absorption values all increase in the wavelength of 350～740 nm.Under the conditions chosen, the CTRZ concentration in the range of 0～10 μg /mL is linear to the A_580nm value.The mole absorption coefficient ε_{580 nm} is 1.30×10⁴ L/(mol·cm).The results shown that the formation of (CTRZ-PtI₆)_n association nanoparticles produce the resonance scattering effect, and it is in violet-red color.