高效液相色谱法拆分雷喏嗪

The Enantiomeric Resolution of Ranolazine by High Performance Liquid Chromatography

中文关键词:  高效液相色谱  直链淀粉三(3,5-二甲基苯基氨基甲酸酯)  手性固定相  手性拆分  雷喏嗪

英文关键词:HPLC  amylose-based chiral stationary phase  chiral phase  chiral resolution  Ranolazine racemate

中文摘要:

      用高效液相色谱法(HPLC)在正相条件下,用自制的涂敷直链淀粉-三(3,5-基苯基氨基甲酸酯)(ADMPC)手性固定相直接拆分了高效低毒的抗心绞痛药物雷喏嗪外消旋体(Ranolazine),并考察了二元及三元流动相体系对样品分离的影响,结果表明,三元流动相中的拆分结果远远好于二元流动相,流动相中不同种类醇改性剂及含量对样品保留时间和立体选择性有不同程度的影响.

英文摘要:

      The chiral resolution ability of a self-made amylase-tris(3,5-dimethylphenylcarbamate) chiral preparation column prepared by our laboratory was investigated. Through optimizing mobile phase we have attained good separation results and type of alcol as modifier and its concentration on chiral were also studied.