极谱法测定阿莫西林胶囊的含量

Determination of Amoxicillinum in Content Capsules by Polarography

中文关键词:  阿莫西林  铜(Ⅱ)  极谱吸附波

英文关键词:amoxicillinum  cupperion  polarographic wave

中文摘要:

      在0.2 mol/L NH₃·H₂O-NH₄Cl支持电解质中(pH=9.00),Cu(Ⅱ)-阿莫西林的配合物在-0.805 V产生灵敏的极谱吸附波,其二阶导数波高与阿莫西林浓度在.0×10^-7～8.0×10^-5 mol/L范围内成线性关系,检出限为2×10^-7 mol/L. 据此建立了测定阿莫西林的新方法,此法已成功地用于药物中阿莫西林的测定.

英文摘要:

      A new and sensitive polarographic wave caused by Cu(Ⅱ) amoxicillinum complex in 0.2 mol/L NH₃·H₂O NH₄Cl(pH=9.00) medium has been investigated. The polargraphic wave is characterized by an adsorptive reduction wave and the peak potential is about-0.805 V (vs.SCE). The peak height is linear with amoxicillinum concentration over a range of 3.0×10^-7 to 8.0×10^-5 mol/L,and the detection limit is 2×10^-7 mol/L. The method has been developed for the determination of amoxicillinum in capsules.